Cardiovascular safety of sulphonylureas: over 40 years of continuous controversy without an answer.
Abdelmoneim AS, Eurich DT, Light PE, Senior PA, Seubert JM, Makowsky MJ, Simpson SH.
Diabetes Obes Metab. 2015 Feb 25. doi: 10.1111/dom.12456. [Epub ahead of print]
PMID: 25711240
Related citations
Select item 25580573
A fatty acid-dependent hypothalamic-DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins.
Yue JT, Abraham MA, LaPierre MP, Mighiu PI, Light PE, Filippi BM, Lam TK.
Nat Commun. 2015 Jan 12;6:5970. doi: 10.1038/ncomms6970.
PMID: 25580573
Related citations
Select item 25354185
Future perspectives in the pharmacological treatment of atrial fibrillation and ventricular arrhythmias in heart failure.
Baczko I, Leprán I, Kiss L, Muntean DM, Light PE.
Curr Pharm Des. 2015;21(8):1011-29.
PMID: 25354185
Related citations
Select item 25118217
Modulation of resistance artery tone by the trace amine β-phenylethylamine: dual indirect sympathomimetic and α1-adrenoceptor blocking actions.
Narang D, Kerr PM, Lunn SE, Beaudry R, Sigurdson J, Lalies MD, Hudson AL, Light PE, Holt A, Plane F.
J Pharmacol Exp Ther. 2014 Oct;351(1):164-71. doi: 10.1124/jpet.114.216523. Epub 2014 Aug 12.
PMID: 25118217
Related citations
Select item 25063541
The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.
Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.
BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.
PMID: 25063541 Free PMC Article
Related citations
Select item 24798548
Intracellular long-chain acyl CoAs activate TRPV1 channels.
Yu Y, Carter CR, Youssef N, Dyck JR, Light PE.
PLoS One. 2014 May 5;9(5):e96597. doi: 10.1371/journal.pone.0096597. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0118385.
PMID: 24798548 Free PMC Article
Related citations
Select item 24634823
Hypothalamic glucagon signals through the KATP channels to regulate glucose production.
Abraham MA, Yue JT, LaPierre MP, Rutter GA, Light PE, Filippi BM, Lam TK.
Mol Metab. 2013 Nov 28;3(2):202-8. doi: 10.1016/j.molmet.2013.11.007. eCollection 2014 Apr.
PMID: 24634823 Free PMC Article
Related citations
Select item 24157879
Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response.
Samokhvalov V, Alsaleh N, El-Sikhry HE, Jamieson KL, Chen CB, Lopaschuk DG, Carter C, Light PE, Manne R, Falck JR, Seubert JM.
Cell Death Dis. 2013 Oct 24;4:e885. doi: 10.1038/cddis.2013.418.
PMID: 24157879 Free PMC Article
Related citations
Select item 24102184
Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation.
Baczko I, Liknes D, Yang W, Hamming KC, Searle G, Jaeger K, Husti Z, Juhasz V, Klausz G, Pap R, Saghy L, Varro A, Dolinsky V, Wang S, Rauniyar V, Hall D, Dyck JR, Light PE.
Br J Pharmacol. 2014 Jan;171(1):92-106. doi: 10.1111/bph.12409.
PMID: 24102184 Free PMC Article
Related citations
Select item 24091325
2-Aminoadipic acid is a biomarker for diabetes risk.
Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE.
J Clin Invest. 2013 Oct;123(10):4309-17. doi: 10.1172/JCI64801. Epub 2013 Sep 16.
PMID: 24091325 Free PMC Article
Related citations
Select item 23668425
Are users of sulphonylureas at the time of an acute coronary syndrome at risk of poorer outcomes?
Nagendran J, Oudit GY, Bakal JA, Light PE, Dyck JR, McAlister FA.
Diabetes Obes Metab. 2013 Nov;15(11):1022-8. doi: 10.1111/dom.12126. Epub 2013 Jun 3.
PMID: 23668425
Related citations
Select item 23627843
Triton X-100 inhibits L-type voltage-operated calcium channels.
Narang D, Kerr PM, Baserman J, Tam R, Yang W, Searle G, Manning-Fox JE, Paulsen IM, Kozuska JL, MacDonald PE, Light PE, Holt A, Plane F.
Can J Physiol Pharmacol. 2013 Apr;91(4):316-24. doi: 10.1139/cjpp-2012-0257. Epub 2013 Jan 15.
PMID: 23627843
Related citations
Select item 23437120
Calreticulin induces dilated cardiomyopathy.
Lee D, Oka T, Hunter B, Robinson A, Papp S, Nakamura K, Srisakuldee W, Nickel BE, Light PE, Dyck JR, Lopaschuk GD, Kardami E, Opas M, Michalak M.
PLoS One. 2013;8(2):e56387. doi: 10.1371/journal.pone.0056387. Epub 2013 Feb 20. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/04c791d5-a71c-493d-b94a-a57b158c5538.
PMID: 23437120 Free PMC Article
Related citations
Select item 22879384
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE.
J Pharmacol Exp Ther. 2012 Nov;343(2):325-32. doi: 10.1124/jpet.112.196949. Epub 2012 Aug 9.
PMID: 22879384 Free Article
Related citations
Select item 22561102
Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection.
Batchu SN, Chaudhary KR, El-Sikhry H, Yang W, Light PE, Oudit GY, Seubert JM.
J Mol Cell Cardiol. 2012 Jul;53(1):43-52. doi: 10.1016/j.yjmcc.2012.04.008. Epub 2012 Apr 27.
PMID: 22561102
Related citations
Select item 22209866
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Lang VY, Fatehi M, Light PE.
Pharmacogenet Genomics. 2012 Mar;22(3):206-14. doi: 10.1097/FPC.0b013e32835001e7.
PMID: 22209866
Related citations
Select item 22187380
The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity.
Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light PE.
Diabetes. 2012 Jan;61(1):241-9. doi: 10.2337/db11-0371.
PMID: 22187380 Free PMC Article
Related citations
Select item 22158969
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.
Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR.
Mol Cell Biol. 2012 Feb;32(4):740-50. doi: 10.1128/MCB.06470-11. Epub 2011 Dec 12.
PMID: 22158969 Free PMC Article
Related citations
Select item 21998401
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.
Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR.
Diabetes. 2011 Dec;60(12):3186-96. doi: 10.2337/db11-0081. Epub 2011 Oct 12.
PMID: 21998401 Free PMC Article
Related citations
Select item 21968738
The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes.
Lang V, Youssef N, Light PE.
Curr Diab Rep. 2011 Dec;11(6):543-51. doi: 10.1007/s11892-011-0233-8. Review.
PMID: 21968738
Related citations
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Abdelmoneim AS, Hasenbank SE, Seubert JM, Brocks DR, Light PE, Simpson SH.
Diabetes Obes Metab. 2012 Feb;14(2):130-8. doi: 10.1111/j.1463-1326.2011.01496.x. Epub 2011 Nov 3. Review.
PMID: 21923736
Related citations
Select item 21774762
Sarcolemmal KATP channel modulators and cardiac arrhythmias.
Baczkó I, Husti Z, Lang V, Leprán I, Light PE.
Curr Med Chem. 2011;18(24):3640-61. Review.
PMID: 21774762
Related citations
Select item 20518849
Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.
Polewicz D, Cadete VJ, Doroszko A, Hunter BE, Sawicka J, Szczesna-Cordary D, Light PE, Sawicki G.
J Cell Mol Med. 2011 May;15(5):1136-47. doi: 10.1111/j.1582-4934.2010.01094.x. Epub 2010 May 26.
PMID: 20518849 Free PMC Article
Related citations
Select item 20413506
Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.
Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE.
Diabetes. 2010 Jul;59(7):1686-93. doi: 10.2337/db09-0630. Epub 2010 Apr 22.
PMID: 20413506 Free PMC Article
Related citations
Select item 20299464
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, Febbraio M, Dyck JR.
Diabetes. 2010 Jun;59(6):1366-75. doi: 10.2337/db09-1142. Epub 2010 Mar 18.
PMID: 20299464 Free PMC Article
Related citations
Select item 23226049
The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes.
Lang V, Light PE.
Pharmgenomics Pers Med. 2010;3:145-61. doi: 10.2147/PGPM.S6969. Epub 2010 Nov 24.
PMID: 23226049 Free PMC Article
Related citations
Select item 20031621
Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen.
Folmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR.
Circ Cardiovasc Genet. 2009 Oct;2(5):457-66. doi: 10.1161/CIRCGENETICS.108.834564. Epub 2009 Jul 15.
PMID: 20031621 Free Article
Related citations
Select item 19587354
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.
Diabetes. 2009 Oct;58(10):2419-24. doi: 10.2337/db09-0143. Epub 2009 Jul 8.
PMID: 19587354 Free PMC Article
Related citations
Select item 19481548
Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.
Soliman D, Hamming KS, Matemisz LC, Light PE.
J Mol Cell Cardiol. 2009 Nov;47(5):595-602. doi: 10.1016/j.yjmcc.2009.05.011. Epub 2009 May 28.
PMID: 19481548
Related citations
Select item 19289642
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.
Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR.
Circulation. 2009 Mar 31;119(12):1643-52. doi: 10.1161/CIRCULATIONAHA.108.787440. Epub 2009 Mar 16.
PMID: 19289642 Free Article
Related citations
Select item 19088806
Diastolic calcium is elevated in metabolic recovery of cardiomyocytes expressing elevated levels of the Na+/H+ exchanger.
Baczkó I, Mraiche F, Light PE, Fliegel L.
Can J Physiol Pharmacol. 2008 Dec;86(12):850-9. doi: 10.1139/Y08-092.
PMID: 19088806
Related citations
Select item 18812316
The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.
Chee MJ, Mörl K, Lindner D, Merten N, Zamponi GW, Light PE, Beck-Sickinger AG, Colmers WF.
J Biol Chem. 2008 Nov 28;283(48):33337-46. doi: 10.1074/jbc.M804671200. Epub 2008 Sep 23. Erratum in: J Biol Chem. 2009 Feb 6;284(6):4040.
PMID: 18812316 Free PMC Article
Related citations
Select item 18635667
Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.
Hamming KS, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE.
Mol Endocrinol. 2008 Oct;22(10):2293-306. doi: 10.1210/me.2008-0053. Epub 2008 Jul 17.
PMID: 18635667
Related citations
Select item 18562309
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR.
J Biol Chem. 2008 Aug 29;283(35):24194-201. doi: 10.1074/jbc.M802869200. Epub 2008 Jun 18.
PMID: 18562309 Free PMC Article
Related citations
Select item 18511848
Hypothalamic protein kinase C regulates glucose production.
Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK.
Diabetes. 2008 Aug;57(8):2061-5. doi: 10.2337/db08-0206. Epub 2008 May 28.
PMID: 18511848 Free PMC Article
Related citations
Select item 18401341
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.
Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK.
Nature. 2008 Apr 24;452(7190):1012-6. doi: 10.1038/nature06852. Epub 2008 Apr 9.
PMID: 18401341
Related citations
Select item 18372336
Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.
Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE.
Endocrinology. 2008 Jul;149(7):3679-87. doi: 10.1210/en.2007-1138. Epub 2008 Mar 27.
PMID: 18372336
Related citations
Select item 18071296
Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte.
León H, Baczkó I, Sawicki G, Light PE, Schulz R.
Br J Pharmacol. 2008 Feb;153(4):676-83. Epub 2007 Dec 10.
PMID: 18071296 Free PMC Article
Related citations
Select item 17606845
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.
Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.
PMID: 17606845 Free Article
Related citations
Select item 17124262
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.
Alvarez BV, Johnson DE, Sowah D, Soliman D, Light PE, Xia Y, Karmazyn M, Casey JR.
J Physiol. 2007 Feb 15;579(Pt 1):127-45. Epub 2006 Nov 23.
PMID: 17124262 Free PMC Article
Related citations